NCT05992571

Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity

The Impact of Acute Oral Ketone Monoester Supplementation on Resting-state Brain Connectivity in Adults With Memory Complaints

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. Interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. Exogenous ketone supplements have been shown rapidly improves brain network function in young adults. Further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. Whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown. This study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.

Conditions

• Cerebrovascular Function
• Cognition

Interventions

Type	Name	Description
OTHER	Placebo	Ingestion of a taste-matched calorie-free placebo drink followed by 90 minutes of rest.
DIETARY_SUPPLEMENT	β-OHB	Ingestion of a high dose \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate (0.6 g β-OHB/kg body weight) followed by 90 minutes of rest.

Timeline

• Start date: 2023-10-25
• Primary completion: 2024-08-01
• Completion: 2024-08-01
• First posted: 2023-08-15
• Last updated: 2023-12-01

Locations

1 site across 1 country: Canada