NCT05989386

Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies

Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial

• Status: Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Dow University of Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are: * Incidence of SSI after intervention * Length of hospital stay Participants will be randomly assigned to two groups receiving either of the two groups: Group A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation. Researchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.

Conditions

• Surgical Site Infection
• Surgical Wound
• Surgical Incision
• Emergency Laparotomies
• Laparotomies
• Post Operative Wound Infection
• Wound Infection
• Seroma

Interventions

Type	Name	Description
PROCEDURE	0.9% saline solution	During emergency laparotomy, after the primary surgical procedure. the sheath will be sutured and the incision site will then be irrigated with three rounds of 1 liter of 0.9% saline solution, which will be completely aspirated before the closure of the incisional wound in experimental group.
PROCEDURE	Povidone-iodine Swab	No intra-operative wound lavage done, and wound would be cleaned with povidone doused swab.

Timeline

• Start date: 2023-04-29
• Primary completion: 2025-09-29
• Completion: 2025-12-29
• First posted: 2023-08-14
• Last updated: 2025-06-18

Locations

1 site across 1 country: Pakistan