NCT05988879

Functional Cure of Hepatitis B in HIV/HBV Co-infected Patients

A Clinical Research on Functional Cure Strategies for Hepatitis B Among HIV/HBV Co-infected Patients in China

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Guangzhou 8th People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Evaluate the potential of ART combined with interferon therapy to achieve functional cure of hepatitis B in HIV/HBV co-infected patients

Detailed description

This is a prospective, non-randomized, clinical observational cohort study. The subjects are the advantageous population for functional cure of hepatitis B in HIV/HBV co-infected patients . Depending on whether interferon therapy is used in the real world , the patients are divided into two groups: the ART combined with interferon group and the ART alone group, with 30 cases in each group. Hepatitis B surface antigen seroclearance rate and seroconversion rate will be observed during the study period.

Conditions

• AIDS
• Hepatitis B

Interventions

Type	Name	Description
DRUG	Peginterferon alfa-2b Injection	The pegylated interferon α-2b injection is administered subcutaneously at a dose of 180ug once a week.

Timeline

• Start date: 2023-08-02
• Primary completion: 2026-08-02
• Completion: 2028-08-02
• First posted: 2023-08-14
• Last updated: 2023-08-14

Locations

1 site across 1 country: China