NCT05988671

Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Comparison of Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Conditions

• Laparoscopic Cholecystectomy
• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	normal Saline	Intraperitoneal route
DRUG	Dexamethasone	Intraperitoneal route
DRUG	Dexmedetomidine	Intraperitoneal route
DRUG	Combination of dexamethasone + dexmedetomidine	Intraperitoneal route

Timeline

• Start date: 2023-08-10
• Primary completion: 2024-08-30
• Completion: 2024-08-30
• First posted: 2023-08-14
• Last updated: 2025-06-18

Locations

2 sites across 1 country: Egypt