NCT05986357

The Relation of High Sensitivity C Reactive Protein and Total Leucocytic Count Levels in Threatened Abortion

The Relation Between Maternal Serum High Sensitivity C Reactive Protein and Total and Differential Leucocytic Count Levels in Healthy Pregnant Women With Threatened Abortion and the Outcome of Pregnancy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 240 (estimated)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

to identify the relation between maternal serum high sensitivity C reactive protein and total and differential leucocytic count values in healthy pregnant women with threatened abortion and the outcome of pregnancy

Detailed description

observational prospective cohort research will be pregnant women attending to obstetrics and gynecology department of University Hospital. After enrollment, participants will be divided into two groups: * Study group: had 120 healthy women presenting with threatened miscarriage. * Control group: had 120 healthy women with an uncomplicated single pregnancy. informed permission will be obtained. All cases subjected to the following: taking complete history, General examination, Special investigations including Obstetric ultrasonography for assessment of gestational age, and exclusion of congenital anomalies or multi-fetal gestation. Laboratory investigations including Estimation of the complete blood picture (CBC), Highly sensitive CRP (HS-CRP) single measurement, Women over 1st trimester abdominal ultrasonographic examination (6-13weeks) using Toshiba with transabdominal transducer probe frequency of 7 MHz to evaluate the following data: Measuring of the fetal crown-rump length (CRL) done to confirm the fetal gestational age and the viability of the fetus. Gestational age will be calculated from the beginning of the last regular menstrual cycle. Women who had hormone therapy or progesterone supplements, as well as pregnancies with a discrepancy between LMP and crown rump length of more than three days, were excluded from the research. Pregnant women will be under close follow up every 2 weeks by: Obstetric U/S, Measure blood pressure and inform us if severe bleeding occurs.

Conditions

• Abortion Early

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	maternal serum C reactive protein	maternal serum high sensitivity C reactive protein
DIAGNOSTIC_TEST	total leucocytic count levels	total leucocytic count levels
DIAGNOSTIC_TEST	differential leucocytic count levels	differential leucocytic count levels

Timeline

• Start date: 2023-07-30
• Primary completion: 2023-10-30
• Completion: 2023-10-30
• First posted: 2023-08-14
• Last updated: 2023-08-14

Locations

1 site across 1 country: Egypt