NCT05985928

Sensory Study: Taste and Tongue Biology

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 121 (actual)
• Sponsor: University of Massachusetts, Amherst · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Researchers will investigate the correlation between a) self-reported dietary intake of foods and beverages, b) intensity of sucrose stimuli, and c) liking rating of sweet stimuli, with the relative expression of the taste receptor genes from human fungiform papillae (TAS1R2 and TAS1R3). \* This research will provide new information on how sweet taste perception is regulated. * The hypothesis: Greater dietary consumption of sugar and sweet foods is associated with reduced expression of the sweet taste receptors. * The results of this study could help to identify pathways to help modify sweet taste perception by uncovering this mechanism. Participants will sample solutions prepared with sweet ingredients, provide salivary DNA, and collect fungiform papillae. This will allow researchers and investigators to compare the relationship between the sweetness of stimuli, genetic differences in sweet taste receptors, and expression levels of sweet taste receptor genes.

Conditions

• Healthy Adults

Timeline

• Start date: 2023-03-20
• Primary completion: 2025-04-20
• Completion: 2025-05-20
• First posted: 2023-08-14
• Last updated: 2025-08-05

Locations

1 site across 1 country: United States