NCT05985148

A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall

A Phase I Dose Escalation Trial for Treatment of Chronic Thoracoabdominal Wall Pain Through Ablation of the Dorsal Spinal Nerve Using Single-Fraction Stereotactic Radiosurgery

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The researchers are doing this study to find out whether stereotactic radiosurgery (SRS) is a safe, practical (feasible), and effective treatment for people with chronic TAWP. The researchers will test different doses of SRS to find the highest dose that causes few or mild side effects.

Conditions

• Thoracoabdominal Wall Pain
• Secondary to Parietal Pleura or Parietal Peritoneum Disease

Interventions

Type	Name	Description
RADIATION	Single-fraction stereotactic radiosurgery (SRS)	Patients will be treated with single-fraction radiation therapy at three dose levels: 70 Gy, 80 Gy, and 90 Gy using image-guided SRS techniques.

Timeline

• Start date: 2023-08-02
• Primary completion: 2028-08-01
• Completion: 2028-08-01
• First posted: 2023-08-14
• Last updated: 2026-01-20

Locations

7 sites across 1 country: United States