NCT05982340

Endogenous Lithium Clearance in Acute Kidney Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: University Hospital of North Norway · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness. Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Detailed description

Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.

Conditions

• Acute Kidney Injury Due to Sepsis
• Proximal Tubule Function
• Lithium Clearance

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Lithium clearance	Blood and urine samples

Timeline

• Start date: 2023-08-01
• Primary completion: 2025-05-20
• Completion: 2025-05-20
• First posted: 2023-08-08
• Last updated: 2025-06-22

Locations

1 site across 1 country: Norway