NCT05976516

CXCL2/CXCL8 Promote Intervertebral Disc Degeneration

Study on the Correlation Between CXCL2/CXCL8 and the Degree of Intervertebral Disc Degeneration and Radiological Progress

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Zhongda Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.

Conditions

• Cytokine
• Intervertebral Disc, Degenerative

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CXCL2/CXCL8	Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

Timeline

• Start date: 2023-08-01
• Primary completion: 2024-03-30
• Completion: 2024-03-30
• First posted: 2023-08-04
• Last updated: 2023-08-04

Locations

1 site across 1 country: China