NCT05973721

Clinical Study of Phage Therapy for Chronic Constipation Efficacy and Safety

To Investigate the Clinical Efficacy and Safety of Phage Therapy for Chronic Constipation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Shanghai 10th People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The overall aim was to evaluate the efficacy of PiB-specific phages for the treatment of refractory constipation through clinical studies, primarily for the publication of scientific papers and to guide the development of phage therapies. The purpose of this study will be subdivided into three aspects from three aspects: target exposure level, target occupation, and functional effects after acting on the target, including:1) The distribution of PIB phage in the intestine of patients with refractory constipation;2) The killing effect of PIB phage on PIB bacteria in refractory constipation patients;And 3) therapeutic effect of PIB phage on patients with refractory constipation.

Conditions

• Pib Specific Phage
• Intractable Constipation

Interventions

Type	Name	Description
BIOLOGICAL	phage	The treatment group was given one phage each time, once a day for two weeks

Timeline

• Start date: 2023-07-01
• Primary completion: 2023-09-01
• Completion: 2023-10-01
• First posted: 2023-08-03
• Last updated: 2023-08-03

Locations

1 site across 1 country: China