NCT05973578

Cardiac RadiothErapy for VEntricular Tachycardia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Objective: To explore in our center the feasibility and safety of a SBRT treatment method for VT. Study population: Patients with ventricular tachycardia that are refractory to dose-escalated antiarrhythmic drugs and where catheter ablation has either already been performed or is deemed to be unsuccessful or associated with high risks. Intervention: Patients will be treated with a stereotactic body radiotherapy technique as a single fraction treatment up to a dose of 25 Gy delivered to the VT substrate defined by electrophysiological mapping. Main study endpoints: The primary aim is to explore the feasibility and safety of a SBRT treatment method for refractory VT. Secondary endpoints include an assessment of the efficacy of the treatment, quality of life, late toxicity and overall survival. Patients will have to fill in a quality-of-life questionnaire before and after the radiotherapy treatment. The risk associated with this trial is an increase in toxicity.

Conditions

• Ventricular Tachycardia

Interventions

Type	Name	Description
RADIATION	Stereotactic radiotherapy	Single-session high dose stereotactic radiotherapy

Timeline

• Start date: 2023-05-23
• Primary completion: 2025-05-01
• Completion: 2026-05-01
• First posted: 2023-08-03
• Last updated: 2023-08-03

Locations

1 site across 1 country: Belgium