NCT05971667

Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

"Effect of Tadalafil, Sildenafil and Pentoxyfylline on Endometrial Thickness and Frozen Embryo Transfer Outcomes

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

Detailed description

A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups. The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Conditions

• IVF

Interventions

Type	Name	Description
DRUG	tadalafil	tadalafil 10 mg one tablet daily
DRUG	Sildenafil	sildenafil 20 mg two tablets daily
DRUG	pentoxifylline	pentoxifylline 400 mg two tabs daily

Timeline

• Start date: 2023-07-30
• Primary completion: 2023-10-30
• Completion: 2023-10-30
• First posted: 2023-08-02
• Last updated: 2023-08-03

Locations

1 site across 1 country: Egypt