NCT05969574

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,059 (estimated)
• Sponsor: ART Fertility Clinics LLC · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

Detailed description

By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function. Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

Conditions

• Infertility, Female
• Miscarriage
• Miscarriage, Recurrent
• IVF

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transvaginal ultrasound	Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation
DIAGNOSTIC_TEST	Blood test AMH	Measurement of AMH performed on the day of first consultation

Timeline

• Start date: 2023-09-09
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2023-08-01
• Last updated: 2025-02-19

Locations

3 sites across 1 country: United Arab Emirates