NCT05967130

Treatment Chronic UTI Post Kidney Transplant

Treatment of Chronic Relapsing Urinary Tract Infection With Bacteriophages in Renal Transplant Patients

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Shahid Beheshti University of Medical Sciences · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Urinary tract infections (UTIs) with extended-spectrum -lactamase (ESBL)-positive Enterobacteriums (ESBL-E) are a common infectious complication of renal transplant recipients, with 10% of patients suffering from UTIs with ESBL-E within the first year posttransplant. Moreover, recurrence rates of UTI caused by ESBL-E are almost three times higher than those by cephalosporin-susceptible Enterobacteriums demonstrating the decreased efficacy of antibiotics in the treatment of these UTIs.

Detailed description

According to each patient's urine culture, resistant urinary tract infections will be treated with specific phages and patients will be followed up with their urine cultures for response to therapy.

Conditions

• Urinary Tract Infections
• Transplant-Related Disorder

Interventions

Type	Name	Description
BIOLOGICAL	Phage	Inserting specific specimen of phages in to the bladder

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-01-01
• Completion: 2024-07-01
• First posted: 2023-08-01
• Last updated: 2025-06-10

Locations

1 site across 1 country: Iran