NCT05965908

Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome

Effect of Liraglutide on Different Parameters (Clinical , Metabolic and Hormonal) in Obese Women With Polycystic Ovary Syndrome

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare the hormonal, metabolic and clinical effects of metformin and liraglutide in infertile women with PCOs.

Detailed description

It is a Prospective randomized controlled trial .The study will include 80 randomly selected infertile women aged between 18 and 45 years, from Gynecology and obstetrics department Beni-Suef University Hospital whom diagnosed with polycystic ovarian syndrome (PCOS), The study will include two groups; each group consists of 40 patients:- * Group1 (n=50) will be treated by liraglutide monotherapy. * Group 2 (n=50) will be treated by metformin monotherapy. * Group 3 (n=50) will be a control group. To assess the metabolic effect of each treatment, the following parameters will be assessed before and after the treatment * To assess the hormonal effect of each treatment, the following tests will be assessed before and after treatment * Total Testosterone (TT) * Dehydroepiandrosterone (DHEA) To assess the clinical effect of the drugs, the following will be assessed before and after treatment: The ovulation was assessed on the tenth or eleventh day of menstruation. The chemical and clinical pregnancy rates were evaluated

Conditions

• Polycystic Ovary

Interventions

Type	Name	Description
DRUG	liraglutide	glucagon-like peptide 1 receptor agonist
DRUG	Metformin	biguanide antihyperglycemic

Timeline

• Start date: 2024-01-30
• Primary completion: 2025-03-30
• Completion: 2025-03-30
• First posted: 2023-07-28
• Last updated: 2026-03-06

Locations

1 site across 1 country: Egypt