NCT05964907

Optimizing Phototesting and Investigating Photobiology of Visible Light

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Henry Ford Health System · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Specific Aim 1: To determine the impact of spectral composition of the VL+UVA1 source on the associated biologic effects. Specific Aim 2: To investigate differential responses of subjects with different skin phototypes to VL+UVA1, including immediate and delayed erythema and pigmentation, and photodamage.

Detailed description

The design of the study consists of a total of 4 visits within a two week period. The first visit consists of VL+UVA1 irradiation with different light source on the opposite site of patients' back. A combination of non-invasive measurements (e.g., photography, redness and color changes of the skin using colorimetry and diffuse reflectance spectrometry) will be conducted throughout the 4 visits. Biopsies will be taken at various time points.

Conditions

• Healthy

Interventions

Type	Name	Description
DEVICE	Light Source B: Visible Light solar simulator (VL + UVA1)	Patients will be radiated with light source B (Visible light solar simulator)
DEVICE	Light Source A: Visible Light solar simulator closer match to sunlight (VL +UVA1)	Patients will be radiated with light source A (Visible light solar simulator closer match to sunlight)

Timeline

• Start date: 2021-10-06
• Primary completion: 2026-12-30
• Completion: 2026-12-30
• First posted: 2023-07-28
• Last updated: 2025-05-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study