NCT05963646

Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients With Geographic Atrophy Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Institute of Molecular and Clinical Ophthalmology Basel · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: —

Summary

This study is a biomarker evaluation study in patients with geographic atrophy secondary to age-related macular degeneration (AMD). The study evaluates microperimetry (fundus-controlled perimetry) and optical coherence tomography imaging for assessing changes in retinal sensitivity and anatomy over time.

Detailed description

The optical coherence tomography (OCT) and microperimetry biomarker evaluation in patients with GA (OMEGA) study aims to systematically compare a panel of established and novel visual function and structural outcome measures for monitoring GA progression. This prospective, natural-history study was performed at a tertiary referral center (University Hospital Basel, PI: Prof. Dr. med. Hendrik P.N. Scholl). The study included a baseline visit and follow-up visits at weeks 12, 24, and 48.

Conditions

• Age-Related Macular Degeneration
• Geographic Atrophy
• Visual Field Defect, Central Scotoma of Both Eyes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Natural history study	Patients were monitored with a panel of visual function tests and imaging modalities. Functional tests included best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), and contrast sensitivity function evaluation (qCSF method). Imaging assessments included fundus autofluorescence, optical coherence tomography and optical coherence tomography angiography.

Timeline

• Start date: 2021-03-16
• Primary completion: 2023-06-23
• Completion: 2023-12-31
• First posted: 2023-07-27
• Last updated: 2025-02-19

Locations

1 site across 1 country: Switzerland