NCT05962255

Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure

The Impact of Slow, Continuous Infusion of Sodium Chloride or Glucose Solution on Diuresis and Urine Composition During Decongestion of Acute Heart Failure Patients

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Wroclaw Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.

Conditions

• Acute Heart Failure
• Congestion
• Heart Failure

Interventions

Type	Name	Description
DRUG	Furosemide intravenous infusion	At baseline, patients will receive a standardised dose of furosemide 1mg/kg (half of the dose administered as bolus and half as in 2h infusion). At the 6th and the 12th hour of the study patients will be reassessed and the need for additional diuretics.
DRUG	Continous intravenous infusion of 0.9% Sodium Chloride solution	Continuous 48h infusion of 0.9% sodium chloride at a fixed rate v= 83 ml/h x 24h = 2l/24h
DRUG	Continous intravenous infusion of 5% Glucose solution	Continuous 48h infusion of 5% Glucose at a fixed rate v= 83 ml/h x 24h = 2l/24h

Timeline

• Start date: 2022-02-01
• Primary completion: 2024-04-01
• Completion: 2024-04-29
• First posted: 2023-07-27
• Last updated: 2024-06-21

Locations

1 site across 1 country: Poland