NCT05961865

Change in Inflammatory State in Patients Undergoing Transcatheter Ablation of Atrial Fibrillation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

It is a non-pharmacological (biological), spontaneous observational study. The main objective is to evaluate the correlation between inflammation markers and local adiposity, clinical risk factors and their possible variation following an AF ablation procedure

Detailed description

The study includes the execution of a sample for each time point for the evaluation of inflammation and fibrosis markers identified so far in the literature, such as Interleukin 6, N-terminal propeptide of procollagen type 1 (P1NP), chitinase-3-like protein 1 (YKL-40), tumor necrosis factor (TNF-alpha), GlycA, proprotein convertase subtilisin/kexin type 9 and omega-3 fatty acids.

Conditions

• Atrial Fibrillation
• Marker of Inflammation
• Inflammation
• Arrhythmia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Markers of inflammation and fibrosis	Will be analyzed the following inflammation markers: Interleukin 6, N-terminal propeptide of type 1 procollagen (P1NP), chitinase-3-like protein 1 (YKL-40), tumor necrosis factor (TNF-alpha), GlycA, proprotein convertase subtilisin/kexin type 9 and omega-3 fatty acids.

Timeline

• Start date: 2023-07-11
• Primary completion: 2027-07-01
• Completion: 2027-08-01
• First posted: 2023-07-27
• Last updated: 2023-09-13

Locations

1 site across 1 country: Italy