NCT05957926

Hyaluronic Acid +Hydroxyapatite Vs Hydroxyapatite in Bone Regeneration

Evaluation the Effect of Hyaluronic Acid With Hydroxyapatite Versus Hydroxyapatite Alone on Bone Regeneration Following Enucleation of Mandibular Odontogenic Cyst (Randomized Clinical Trial)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Evaluation of the effect of hyaluronic acid with hydroxyapatite versus hydroxyapatite alone on bone regeneration following enucleation of mandibular odontogenic cyst.

Detailed description

During cyst enucleation , There's resultant decrease in bone density especially in large defects .Therefore, it may be needed for a bone grafts and bone regenerative materials to improve quality of bone .The rationale is to evaluate hyaluronic acid with hydroxyapatite as a bone quality improvement material following cyst enucleation, which would provide significant bone regeneration. Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it is stimulate bone remodeling by generating surface active moieties or cell signaling process while Hyaluronic acid and it's derivatives has been widely used for bone regeneration and it has a good potential for osteogenesis and mineralization

Conditions

• Bone Loss
• Bone Lesion

Interventions

Type	Name	Description
PROCEDURE	hyaluronic acid added to hydroxyapetite	1. The procedure will be performed under complete aseptic condition, and the surgical field will be swabbed with povidone iodine solution before the operation . 2. Surgical procedure will be performed under local anesthesia (Articaine 4% with 1:100,000 adrenaline ) . 3. A full thickness mucoperiosteal flap will be reflected exposing the area of interest containing the lesion . 4. The pathological lesion will be exposed using rose head bur on low-speed handpiece under copious irrigation by normal saline . 5. The whole pathological tissues will be enucleated and sent for histopathological examination. 6. The cavity will be curetted again to remove any remaining tissues and irrigated with 0.9% normal saline . 7. hydroxyapetite with hyaluronic acid will be inserted in the bony cavity to initiate healing . 8. The flap will be repositioned and sutured with interrupted 3-0 Vicryl suture .
PROCEDURE	Hydroxyapatite alone	1. The procedure will be performed under complete aseptic condition, and the surgical field will be swabbed with povidone iodine solution before the operation . 2. Surgical procedure will be performed under local anesthesia (Articaine 4% with 1:100,000 adrenaline ) . 3. A full thickness mucoperiosteal flap will be reflected exposing the area of interest containing the lesion . 4. The pathological lesion will be exposed using rose head bur on low-speed handpiece under copious irrigation by normal saline . 5. The whole pathological tissues will be enucleated and sent for histopathological examination. 6. The cavity will be curetted again to remove any remaining tissues and irrigated with 0.9% normal saline . 7. hydroxyapetite will be inserted in the bony cavity to initiate healing . 8. The flap will be repositioned and sutured with interrupted 3-0 Vicryl suture .

Timeline

• Start date: 2023-10-01
• Primary completion: 2024-08-01
• Completion: 2025-01-01
• First posted: 2023-07-24
• Last updated: 2023-09-13

Locations

1 site across 1 country: Egypt