Trials / Completed
CompletedNCT05954923
The Glucagonotropic Effect of Amino Acids in Humans
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 12 (actual)
- Sponsor
- University Hospital, Gentofte, Copenhagen · Academic / Other
- Sex
- Male
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
The objective of the study is to delineate the glucagonotropic signal exerted by selected amino acids in human subjects as well as the metabolic clearance rate of these amino acids after intravenous infusion
Detailed description
After being informed about the study and the potential risks, each participant giving written informed consent will participate in six experimental days. The glucagonotropic effect and metabolic clearance of selected amino acids and saline (placebo), respectively, will be evaluated in 12 healthy individuals. After screening, each participant will undergo 6 double-blinded experimental days performed in randomized order. The experimental days will each last 75 minutes. The amino acids selected for the experiment are glutamine, arginine, alanine, leucine and proline.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Amino acid bolus infusion | Equimolar bolus infusions of amino acids or saline (placebo) |
Timeline
- Start date
- 2023-09-05
- Primary completion
- 2023-12-20
- Completion
- 2023-12-20
- First posted
- 2023-07-20
- Last updated
- 2024-05-09
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT05954923. Inclusion in this directory is not an endorsement.