NCT05952817

Effect of Virtual Reality on Pain and Function in Children With Sickle Cell Disease: A Randomized Controlled Trial

The Effect of Virtual Reality on Pain, Physical Function, and Health-related Quality of Life in Children With Sickle Cell Disease: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Afnan Bkri · Other Government
• Sex: All
• Age: 8 Years – 13 Years
• Healthy volunteers: Not accepted

Summary

Significance or rationale of the study: Virtual reality (VR) is a promising non-pharmacological pain management tool. It enhances motor function by promoting cortical reorganization and neuroplasticity. Its multimodal biofeedback engages sensory and cognitive functions, making therapy interactive, motivating, and easy to understand. With strong rehabilitation potential, VR helps patients adapt to real-world movements (Laver, 2020). Initially used for procedural pain management, VR is now expanding into chronic pain rehabilitation by encouraging engagement with difficult or avoided movements (Griffin et al., 2020). Additionally, VR offers a dynamic alternative to traditional exercises, improving adherence and outcomes. Integrating entertainment into therapy can motivate children, enhancing their physical and psychological well-being. Recently, a few studies revealed an improvement in vaso-occlusive episodes (VOE) after VR treatment (Agrawal et al., 2019). However, efficacy studies are needed to assess VR's potential benefits. Additionally, data regarding VR's efficacy on daily pain, functional mobility, and HRQOL as complementary therapy are limited

Detailed description

1. To investigate the effect of VR in reducing daily pain in children with SCD 2. To evaluate the impact of VR on improving functional mobility in children with SCD. 3. To examine the changes in PedsQL in children with SCD after engaging in VR experiences. 4. To evaluate the safety and satisfaction of fully immersive VR therapy in children with

Conditions

• SCD

Interventions

Type	Name	Description
DEVICE	virtual reality	Virtual reality (VR) technology is a new medical intervention technique founded on the principle of distraction, providing real perceptual stimuli such as visual images, spatial sounds, tactile, and sensory feedback stimuli.(Zhang et al., 2022)

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-02-01
• Completion: 2024-02-29
• First posted: 2023-07-19
• Last updated: 2025-06-18

Locations

1 site across 1 country: Saudi Arabia