NCT05946616

Spectral Characteristics of Memory Transformation

Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Transcranial alternating current stimulation (tACS) combined with behavioral intervention	Transcranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference).
OTHER	Inactive (sham) stimulation combined with behavioral intervention	Inactive (sham) stimulation combined with behavioral intervention (memory interference)

Timeline

• Start date: 2023-07-01
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2023-07-14
• Last updated: 2026-04-07

Locations

1 site across 1 country: United States