NCT05941429

Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride

Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride in a Group of Preschool Children

• Status: Active Not Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 3 Years – 5 Years
• Healthy volunteers: Accepted

Summary

This study will be conducted to test the cariostatic effect of Nano Silver Fluoride in a comparison to Silver Diamine Fluoride in a group of preschool children.

Detailed description

Silver Diamine Fluoride has offered a non-invasive and easily performed method to manage dental caries in very young children.Studies shows that SDF has been proven to arrest caries in cavitated lesions and to prevent caries in sound teeth as Fluoride is effective in enhancing the remineralization of dental hard tissue and silver ion acts as an antibacterial agent. However, It was found that silver causes staining to the dental tissues with a black discoloration, which can be considered to be a main drawback specifically, when it is used on anterior teeth. Nano-silver fluoride varnish preparation showed high efficacy in arresting caries progression in primary teeth without causing black discoloration to the tissues.Silver diamine fluoride (SDF) . Benefits for patient: 1. Non-invasive treatment leading to reduce patient anxiety and stress. 2. No drilling and filling. 3. Protects against further caries progression. Benefits for the practitioner: 1. Provide alternative treatment options. 2. Pain-free procedure that facilitates child management and saves time. Benefits for the community: 1. Increasing overall oral health 2. Provides more information by testing new material 3. To provide better service quality.

Conditions

• Dental Caries in Children

Interventions

Type	Name	Description
DRUG	Nano-Silver Fluoride	NSF is a varnish which has been introduced as experimental formulation . the laboratory synthesis of NSF was carried out in a nano techonolgy center .
DRUG	Silver diamine fluoride	38% silver diamine fluoride

Timeline

• Start date: 2024-02-07
• Primary completion: 2024-11-01
• Completion: 2024-12-01
• First posted: 2023-07-12
• Last updated: 2024-10-16

Locations

1 site across 1 country: Egypt