NCT05941377

China Antihypertensive Trial for Intracranial Aneurysm (ChATIA-1)

Enhanced Versus Standard Blood Pressure Lowering on Intracranial Aneurysm Rupture or Growth

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 577 (actual)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized controlled trial is to evaluate the benefits and safety of controlled hypotension in Chinese patients with unruptured intracranial aneurysms(UIA). The main questions it aims to answer are: * To provide high-level evidence of the benefits and safety of controlled hypotension in patients with UIA. * To provide evidence-based medical evidence for blood pressure control of patients with UIA in neurosurgery, and promote the progress of accurate individual management of patients. In this study, the main intervention is enhanced blood pressure lowering in patients with UIA. All Patients will be randomly assigned to either the standard blood pressure lowering (SBPL) group or the enhanced blood pressure lowering (EBPL) group.

Conditions

• Unruptured Intracranial Aneurysm

Interventions

Type	Name	Description
OTHER	blood pressure lowering	For EBPL group, patients are required to keep blood pressure at 100-120 mmHg. For SBPL group, patients are required to keep blood pressure at 120-140 mmHg.

Timeline

• Start date: 2023-07-01
• Primary completion: 2026-01-19
• Completion: 2026-01-19
• First posted: 2023-07-12
• Last updated: 2026-04-07

Locations

1 site across 1 country: China