NCT05940467

Acute Sleep Loss and Arterial Stiffness

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 20 Years – 29 Years
• Healthy volunteers: Accepted

Summary

The overarching goal of this study is to mimic a night shift work like schedule and characterize circadian variation in Pulse Wave Velocity (PWV), a measure of arterial stiffness, and determine the impact of acute loss of sleep like that experienced by shift workers on PWV.

Detailed description

Night shift work is associated with increased risk of cardiovascular disease (CVD). Pulse wave velocity (PWV) is a commonly used non-invasive measure of arterial stiffness and is strongly associated with CVD. Previous research links sleep loss, like that experienced by shift workers, to elevated levels or abnormal levels of PWV. In addition, there is some research that shows circadian variation in PWV, which has implications for future studies and when PWV should be assessed. The overarching goal of this study is to characterize circadian variation in PWV and determine the impact of acute loss of sleep on PWV during a schedule like that experienced by night shift workers.

Conditions

• Arterial Stiffness

Interventions

Type	Name	Description
OTHER	Sleep Loss	Participants will undergo periods of sleep loss in a laboratory setting and be monitored hourly for changes in indicators of arterial stiffness (i.e., pulse wave velocity).

Timeline

• Start date: 2023-07-11
• Primary completion: 2024-05-30
• Completion: 2024-05-30
• First posted: 2023-07-11
• Last updated: 2024-06-04

Locations

1 site across 1 country: United States