NCT05939479

Antistaphylococcal Betalactam and Emergence of Resistance

Impact of Antistaphylococcal Penicillins and Cefazolin on the Emergence of Resistance in French Hospitals

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 644 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Antistaphylococcal penicillins are recommanded as first-line agent in methicillin-suceptible Staphylococcus aureus bacteraemia. Several studies in progress are investigating the efficacy and safety of cefazolin compared with antistaphylococcal penicillins. Cefazolin has broader spectrum than antistaphylococcal penicillins. The hypothesis of this project is that cefazoline could be responsible for a higher rate of bacterial resistance. The aim is to study the association between the emergence of bacterial resistance and the consumption of cefazolin and antistaphylococcal penicillins.

Conditions

• Bacterial Resistance
• Methicillin-Sensitive Staphylococcus Aureus Infection

Timeline

• Start date: 2018-01-01
• Primary completion: 2023-05-01
• Completion: 2023-06-01
• First posted: 2023-07-11
• Last updated: 2025-08-08

Locations

1 site across 1 country: France