NCT05936710

Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite Using Citrate- vs Acetate-based Dialysate

Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite (ICU) Using Citrate- vs Acetate-based Dialysate

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Centre Hospitalier de Bethune · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During intermittent hemodialysis (IHD), the occurrence of intradialytic hemodynamic instability (IHI) is frequent in ICU and impacted morbidity and mortality. Bicarbonate dialysate buffer improves hemodynamic tolerance compared to acetate dialysate buffer. However, bicarbonate dialysate buffer still contains a lower concentration of acetate, which could contribute to hemodynamic instability. Recently, citrate-based dialysate in bicarbonate hemodialysis instead of acetate have been proposed. They have the appropriate authorizations for routine use. The aim of this study is to compare acetate- vs citrate-based dialysate in terms of hemodynamic tolerance and effectiveness.

Conditions

• Intradialytic Hypotension

Interventions

Type	Name	Description
DEVICE	ACETATE based dialysate	Intermittent hemodialysis with an acetate based dialysate.
DEVICE	CITRATE based dialysate	Intermittent hemodialysis with an citrate based dialysate.

Timeline

• Start date: 2023-12-07
• Primary completion: 2027-07-01
• Completion: 2027-07-01
• First posted: 2023-07-10
• Last updated: 2026-01-06

Locations

4 sites across 1 country: France