NCT05935605

Pulmonary Hypertension in Left Heart Disease

Comparison of Noninvasively-Obtained Echocardiographic Doppler Parameters With Simultaneously-Measured Invasive Hemodynamics in Patients Referred for Right Heart Catheterization

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and blood sampling.

Conditions

• Pulmonary Hypertension
• Pulmonary Vascular Disease
• Left Heart Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transthoracic Echocardiography (TTE)	Transthoracic echocardiography using ultrasound waves will be conducted during the rest and exercise phases of the clinically indicated invasive hemodynamic assessment by right heart catheterization to gather additional measurements of right ventricular function.
DIAGNOSTIC_TEST	Lung ultrasound	A lung ultrasound, which uses sound waves to produce images of the lungs, will be used to assess extravascular lung fluid during the rest and exercise phases of the clinically indicated invasive hemodynamic assessment by right heart catheterization.

Timeline

• Start date: 2023-07-20
• Primary completion: 2028-05-01
• Completion: 2028-05-01
• First posted: 2023-07-07
• Last updated: 2026-03-05

Locations

1 site across 1 country: United States