NCT05934929

Contribution of Residual Tumour DNA Testing on the Surgical Bed

Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Centre Henri Becquerel · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.

Detailed description

Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor. Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision

Conditions

• Squamous Cell Carcinoma of the Oral Cavity

Interventions

Type	Name	Description
OTHER	Circulating tumor DNA detection	biological assessment on operating bed to detect residual circulating tumor DNA

Timeline

• Start date: 2024-01-08
• Primary completion: 2025-12-22
• Completion: 2027-12-29
• First posted: 2023-07-07
• Last updated: 2026-01-02

Locations

2 sites across 1 country: France