Trials / Active Not Recruiting
Active Not RecruitingNCT05933681
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- Sponsor
- Vanderbilt University Medical Center · Academic / Other
- Sex
- All
- Age
- 40 Years
- Healthy volunteers
- Not accepted
Summary
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Neural recordings and stimulation | Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off. |
Timeline
- Start date
- 2023-07-06
- Primary completion
- 2025-07-30
- Completion
- 2026-05-30
- First posted
- 2023-07-06
- Last updated
- 2025-12-15
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05933681. Inclusion in this directory is not an endorsement.