NCT05933616

Analysis of Volatile Organic Compounds in Patients With Type 1 Diabetes in Induced Hypoglycaemia With a Breath Analyser

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Bern · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The breath analysis (BreathSpec® device) data of all participants that were included into the VAARA study (NCT05771090) will be analysed, this includes data from up to 40 breath samples from each of the 10 participants who underwent 2 insulin-induced hypoglycaemic episodes during two visits. The primary objective is to find a possible association between volatile organic compounds (VOCs) measured by the BreathSpec® device and blood glucose. For this we will use descriptive statistics, correlation coefficients, as well as a Principal Component Analysis and a partial least squares discriminant analysis. Furthermore, the time lag between hypoglycaemia onset and change in VOCs will be quantified.

Conditions

• Diabetes Mellitus
• Metabolic Disease
• Glucose Metabolism Disorders
• Endocrine System Diseases

Interventions

Type	Name	Description
DEVICE	Device: Sokru device	Different induced glycaemic states in people living with diabetes (PwD).

Timeline

• Start date: 2023-04-20
• Primary completion: 2023-06-16
• Completion: 2024-07-31
• First posted: 2023-07-06
• Last updated: 2024-08-16

Locations

1 site across 1 country: Switzerland