NCT05933291

Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS

Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS: an Analysis of the Effectiveness of Steroid Therapy and a Comparison Between COVID-19 ARDS and ARDS From Other Etiologies

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: —

Summary

The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are: * Differences between patients with COVID-19 ARDS before and after steroid treatment in BALF single cell landscape, as well as patients with different prognosis. * Differences between COVID-19 and non COVID-19 ARDS patients in BALF single cell landscape. Participants will Choose whether to use or not to utilize steroid treatment based on conditions.

Detailed description

Collect BALF from COVID-19 and non-COVID-19 ARDS patients both before and during remission, then perform single-cell sequencing.

Conditions

• ARDS: Acute Respiratory Distress Syndrome
• Covid19

Interventions

Type	Name	Description
DRUG	steroid	Moderate- or high-dose steroids

Timeline

• Start date: 2022-09-24
• Primary completion: 2023-02-09
• Completion: 2023-03-15
• First posted: 2023-07-06
• Last updated: 2023-07-06

Locations

1 site across 1 country: China