NCT05932693

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

Examine the Effects of Novel E-cigarette Constituents and Determining Appropriate Concentrations Among Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

Detailed description

This pilot study will establish low and high concentrations of both WS-3 and menthol concentrations to test in the main study. An anticipated 30 adult e-cigarette users will participate in one laboratory session during which participants will be exposed to e-liquids containing five different concentrations of two different cooling flavors without nicotine (10 e-liquids total). Participants will rate "coolness" using the generalized Labeled Magnitude Scale (gLMS). Using averages of participant ratings, we will select a low concentration of each constituent that is rated as more than "barely detectable" but less than "moderate" to ensure that cooling is weak but clearly perceptible. For the high concentration of each constituent, we will select a concentration that on average falls between "strong" and "very strong" to identify a strong cooling sensation while avoiding sensations that would also be uncomfortable.

Conditions

• E-Cig Use

Interventions

Type	Name	Description
OTHER	E-liquid coolant (WS-3, 0.05%)	Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.05%.
OTHER	E-liquid coolant (WS-3, 0.1%)	Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.1%.
OTHER	E-liquid coolant (WS-3, 0.5%)	Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 0.5%.
OTHER	E-liquid coolant (WS-3, 1.0%)	Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 1.0%.
OTHER	E-liquid coolant (WS-3, 2.0%)	Adult users of e-cigarette will be exposed to five e-liquid coolants WS-3: 2.0%.
OTHER	E-liquid coolant (menthol, 0.05%)	Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.05%.
OTHER	E-liquid coolant (menthol, 0.1%)	Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.1%.
OTHER	E-liquid coolant (menthol, 0.5%)	Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 0.5%.
OTHER	E-liquid coolant (menthol, 1.0%)	Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 1.0%.
OTHER	E-liquid coolant (menthol, 2.0%)	Adult users of e-cigarette will be exposed to five e-liquid coolants menthol: 2.0%.
OTHER	E-liquid coolant (WS-23, 0.05%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.05%.
OTHER	E-liquid coolant (WS-23, 0.1%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.1%.
OTHER	E-liquid coolant (WS-23, 0.5%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 0.5%.
OTHER	E-liquid coolant (WS-23, 1.0%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 1.0%.
OTHER	E-liquid coolant (WS-23, 2.0%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 2.0%.
OTHER	E-liquid coolant (WS-23, 4.0%)	Adult users of e-cigarette will be exposed to six e-liquid coolants WS-23: 4.0%.

Timeline

• Start date: 2024-09-03
• Primary completion: 2025-01-09
• Completion: 2025-01-09
• First posted: 2023-07-06
• Last updated: 2026-02-18
• Results posted: 2026-01-22

Locations

1 site across 1 country: United States