NCT05928689

Behavioral and Pharmacological Reconsolidation Interference in Misophonia

Misophonia-Related Memory Modification Using Reconsolidation Mechanisms: Pharmacological and Behavioral Manipulation

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 141 (actual)
• Sponsor: Icahn School of Medicine at Mount Sinai · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

One of the core processes presumably underlying misophonia - a condition characterized by decreased tolerance for specific sounds - is associative learning. Using behavioral, computational, and neural analyses of emotional learning and memory processes to understand the unknown behavioral and neural mechanisms underlying misophonia's associative learning and memory, the study team will evaluate whether interference with the reconsolidation of a reactivated misophonia memory with propranolol can alleviate aversive reaction to misophonia-related cues.

Conditions

• Misophonia

Interventions

Type	Name	Description
DRUG	Propranolol Hydrochloride tablet	Single dose of 40 mg propranolol tablet
BEHAVIORAL	Reminder	Reactivation of misophonia trigger memory
BEHAVIORAL	Counterconditioning	Counterconditioning will consist of presentation of misophonia cues paired with monetary rewards.
DRUG	Placebo	Matching placebo tablet

Timeline

• Start date: 2023-06-02
• Primary completion: 2024-09-30
• Completion: 2024-09-30
• First posted: 2023-07-03
• Last updated: 2024-10-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study