NCT05925244

The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

A Preliminary Study on the Effect of Loaded and Unloaded Exercise on Anabolic and Turnover Activity of Articular Cartilage in Healthy Young Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Control Condition	Control (no alteration to body mass).
OTHER	+12% Body Mass	Loaded walking exercise (12% increase in body mass using a weighted vest).
OTHER	-12% Body Mass	Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Timeline

• Start date: 2019-09-27
• Primary completion: 2020-03-01
• Completion: 2020-03-01
• First posted: 2023-06-29
• Last updated: 2023-07-03

Locations

1 site across 1 country: Canada