NCT05924230

Dose Responsive Study of Ringer's Lactate Solution in Prevention of Post-induction Hypotension

Dose Responsive Study of Ringer's Lactate Solution in Prevention of Post-induction Hypotension Predicted by Inferior Vena Cava Collapsibility Index in Patients Receiving General Anesthesia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Tata Main Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To assess the dose responsiveness of ringer lactate solution in prevention of post-induction hypotension predicted by Ultrasound guided Inferior Vena Cava diameter in patients receiving General anesthesia. OBJECTIVES Primary - To find the optimum preloading dosage of Ringer Lactate to prevent post induction hypotension. Secondary - To find the predictive incidence of Post-induction hypotension according to age, gender, type of surgery and comorbidities.

Detailed description

All patients, after Ultrasonographic Inferior vena cava collapsibility index calculation, will receive Lactated Ringer's solution as per body weight and as per their allocated group in the receiving area. After induction inside the Operating Room, All patients will be monitored continuously using Electrocardiography, pulse oximetry, noninvasive Blood pressure measurement and capnography . Heart rate, Systolic - Diastolic - Mean blood pressure, Oxygen saturation will be monitored as follows : 1. Baseline parameters - Prior to administration of intravenous Ringer's lactate solution 2. T0 (after administration of intravenous Ringer's lactate solution but prior to induction of anaesthesia), 3. T1-T10 (every minute for first 10 mins after induction of anaesthesia) Our institutional standard practice of induction of Anaesthesia with Fentanyl (2 μg/kg), Propofol (2 mg/kg) and Vecuronium (0.1mg/kg ) will be followed and intubation will be done only after first 10 mins post induction. Amount of Mephentermine needed to correct hypotension despite RL infusion will also be calculated.

Conditions

• Post Induction Hypotension

Interventions

Type	Name	Description
OTHER	RL 10ml/kg	Inferior vena cava collapsibility index of all patients will be calculated by ultrasonography and if it is \>50%, then patients of this group (Group 1) will receive Ringer's lactate 10ml/kg before induction in the receiving area
OTHER	RL 15ml/kg	Inferior vena cava collapsibility index of all patients will be calculated by ultrasonography and if it is \>50%, then patients of this group (Group 2) will receive Ringer's lactate 15ml/kg before induction in the receiving area

Timeline

• Start date: 2023-04-01
• Primary completion: 2024-06-30
• Completion: 2024-08-31
• First posted: 2023-06-29
• Last updated: 2023-06-29

Locations

1 site across 1 country: India