NCT05917392

Effects of Kimchi Supplementation on Gut Microbiota, DNA Methylation and Serum Proteomes

Effects of Polyphenol and Lactobacillus Rhamnosus Supplementation in Fermented Vegetables (Kimchi) on Gut Microbiota, DNA Methylation and Serum Proteomes in Overweight and Obese Women

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: Female
• Age: 35 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Participants will ask to answer questionnaire related to general characteristic, lifestyle, dietary pattern and undergo physical examination and measurement of body composition. The subjects will be divided into 2 groups: healthy control and intervention. The intervention group was divided into 3 subgroups: the fermented vegetable (kimchi) group, the kimchi supplemented with polyphenol (Vitexin) group, or the kimchi supplemented with probiotic (Lactobacillus rhamnosus) group. The intervention group will be instructed to consume 1 pack of kimchi per day (50 g/pack) with lunch for 2 months.

Detailed description

The subjects will be divided into 2 groups: healthy control and intervention. The intervention group was divided into 3 subgroups: the fermented vegetable (kimchi) group, the kimchi supplemented with polyphenol (Vitexin) group, or the kimchi supplemented with probiotic (Lactobacillus rhamnosus) group. The intervention group will be instructed to consume 1 pack of kimchi per day (50 g/pack) with lunch for 2 months. During the study, participants will be strongly encouraged to avoid consuming prebiotics or probiotic supplements, as well as foods such as yogurt, sour milk, fermented vegetables, and fermented fruits, especially 2 weeks before the blood and fecal examination. Compliance will be assessed by monitoring product side effects through follow-up phone calls every week to check on participants' symptoms and assessing the number of sachets or packs they actually consume.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fermented Vegetables (Kimchi) supplementation	Fermented Vegetables (Kimchi) supplementation with 50 gm daily for two months and effects of DNA methylation, serum proteome and microbiota
DIETARY_SUPPLEMENT	probiotic	Supplementation with Kimchi plus LGG 50 grams daily for two months
DIETARY_SUPPLEMENT	polyphenol	Supplementation with Kimchi plus polyphenol 50 grams daily for two months

Timeline

• Start date: 2023-06-15
• Primary completion: 2023-11-30
• Completion: 2024-07-31
• First posted: 2023-06-23
• Last updated: 2023-06-23

Locations

1 site across 1 country: Thailand