NCT05917132

Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite production from a meal sequence rich in saturated fatty acids (SFA) or the same meals but rich in polyunsaturated fatty acids (PUFA) in individuals with or without obesity and Type 2 diabetes (T2D)

Detailed description

The gut microbiota interacts with the host's enteric and systemic functions through the production of gut microbiota-derived metabolites. A subset of these metabolites, the endocannabinoids (eCB) and their congeners are derived from fatty acids and play a crucial role in metabolic health. The research project aims to study gut microbiota-derived metabolites, including the eCB and their congeners, in response to a 2-day diet rich in polyunsaturated fatty acids or rich in saturated fatty acids in individuals with or without abdominal obesity and type 2 diabetes. The investigators hope to better understand the kinetic production of circulating endocannabinoidome mediators derived from fatty acids in the diet.

Conditions

• Obesity, Abdominal
• Diabete Type 2

Interventions

Type	Name	Description
OTHER	Nutritionnal intervention	Participants will be provided with meals corresponding to each diet during the week. Participants will be required to eat only the meals provided.

Timeline

• Start date: 2023-06-12
• Primary completion: 2024-05-31
• Completion: 2024-12-01
• First posted: 2023-06-23
• Last updated: 2025-06-27

Locations

1 site across 1 country: Canada