Trials / Completed
CompletedNCT05916625
Exploratory Study of the Expression of the Serotonergic 5-HT4 Receptor in Parkinson's Disease
Exploratory Study of the Expression of the Serotonergic 5-HT4 Receptor in Parkinson's
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- Hospices Civils de Lyon · Academic / Other
- Sex
- All
- Age
- 50 Years – 85 Years
- Healthy volunteers
- Accepted
Summary
The research aim to study in detail the motor, cognitive and affective modifications of Parkinsonian patients (compared to control subjects) at a moderate stage of the disease and to analyze by positron emission tomography (PET) imaging with the specific radioligand \[11C\]SB207145 the expression levels of this 5-HT4 receptor. At the same time, the study will monitor the impact of the 5-HTTLPR polymorphisms of Serotonin Transporter (SERT) and Brain-derived neurotrophic factor (BDNF) Val66Met on the expression of the 5-HT4 receptor in subjects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | neuropsychological assessment | a consultation to assess cognitive and psycho-behavioral functions with questionnaires |
| OTHER | biological sample | 10 mL intravenous whole blood collection in EDTA tube |
| PROCEDURE | medical imagery | Pet scan with the specific radioligand \[11C\]SB207145 and MRI |
Timeline
- Start date
- 2023-12-07
- Primary completion
- 2025-09-29
- Completion
- 2025-09-29
- First posted
- 2023-06-23
- Last updated
- 2025-10-07
Locations
2 sites across 1 country: France
Source: ClinicalTrials.gov record NCT05916625. Inclusion in this directory is not an endorsement.