NCT05913271

Study on the Correlation Between NAT2(N-acetyltransferase2) Gene Polymorphism and CrCl(Creatine Clreance) and the Efficacy and Safety of Levosimendan in Patients With Severe Heart Failure

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 352 (estimated)
• Sponsor: Yi Han · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

1. To evaluate the efficacy and safety of levosimendan in the treatment of heart failure ; 2. Guide patients to apply levosimendan individually and establish a dose adjustment program.

Detailed description

The efficacy and safety of levosimendan in Chinese patients with different acetylmetabolites and CrCl(Creatine clreance) were re-evaluated after marketing. The population pharmacokinetics of different populations was studied, and the patients were guided to apply levosimendan individually and establish a dose adjustment program.

Conditions

• Heart Failure
• Levosimendan
• Efficacy
• Safety

Timeline

• Start date: 2023-05-30
• Primary completion: 2025-05-30
• Completion: 2025-05-30
• First posted: 2023-06-22
• Last updated: 2023-06-22

Locations

1 site across 1 country: China