NCT05912881

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Conditions

• Anosmia
• Skull Base Neoplasms

Interventions

Type	Name	Description
OTHER	Olfactory training	Participants perform olfactory training using sticks filled with scented essential oils.
OTHER	Placebo training	Participants perform olfactory training using sticks filled with unscented medium chain triglycerides.

Timeline

• Start date: 2023-02-01
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2023-06-22
• Last updated: 2026-02-18

Locations

1 site across 1 country: United States