NCT05911932

Investigating Genetic Status in Patients Presenting to Clinic

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The causes of neurodegenerative dementias such as Frontotemporal Dementia, Lewy Body Disease and Alzheimer's disease are still largely unknown. While the contribution of some genetic mutations and polymorphisms is associated with autosomal dominant patterns of inheritance of these dementias, in many cases, the specific causative mutation in these families is not yet identified. Further, in many patients, polygenic risk is thought to give rise to pathophysiologic changes, but which specific genes affect risk are largely yet unknown. By examining genotypes in patients that present to our Cognitive Neurology and Alzheimer's Research Clinic with suspected or confirmed neurodegenerative dementia, or have a history of a familial dementia, we aim to help identify and characterize genetic mutations or polymorphisms that give rise to neurodegenerative diseases.

Conditions

• Dementia, Frontotemporal
• Alzheimer Dementia (AD)
• Lewy Body Dementia (LBD)

Interventions

Type	Name	Description
OTHER	Biosample collection.	Blood draw.

Timeline

• Start date: 2023-10-20
• Primary completion: 2038-08-01
• Completion: 2043-08-01
• First posted: 2023-06-22
• Last updated: 2025-03-04

Locations

1 site across 1 country: Canada