NCT05909540

A Prospective Study of Natural History and Clinical Outcomes for Basilar Invagination

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

A Prospective Study of Natural History and Clinical Outcomes for Basilar Invagination

Detailed description

Since basilar invagination was reported, its pathogenesis has been considered both primary and secondary. Surgical treatment methods emerged in an endless stream, and a hundred schools of thought contend. However, the link between the symptoms and imaging has not been studied in detail. We prospectively enrolled patients with basilar depression, and then explored the natural history of the disease and the clinical outcomes of early intervention.

Conditions

• Basilar Invagination

Interventions

Type	Name	Description
PROCEDURE	Posterior facet distraction and fusion	With the patient in prone position, cervical traction was only intraoperatively after anesthesia with weights of approximately 5-8 kg during surgery. Monitoring of the spinal cord with motor evoked potential and somatosensory evoked potential were used throughout the surgery. Using a posterior midline incision, the occiput to the C2 spinous process was surgically exposed, separated to the lateral edge of the C1-2 joint, and cut off at the C2 nerve root to expose the C1-2 articular surface Quantitative reduction techniques included the following steps .1) Facet joint release and cage implantation technique 2)Adjusting POCA by cantilever and occipitocervical fixation technique.

Timeline

• Start date: 2022-02-06
• Primary completion: 2023-12-01
• Completion: 2024-06-30
• First posted: 2023-06-18
• Last updated: 2023-06-18

Locations

1 site across 1 country: China