NCT05907629

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

Conditions

• Stroke
• Intracranial Atherosclerotic Stenosis (ICAS)

Interventions

Type	Name	Description
OTHER	MRI	Additional MRI to the CAPTIVA study at baseline and 12 months follow-up

Timeline

• Start date: 2024-06-24
• Primary completion: 2029-03-31
• Completion: 2029-03-31
• First posted: 2023-06-18
• Last updated: 2025-08-27

Locations

13 sites across 1 country: United States