NCT05906420

Posterior Circulation ASTRAL Prognostic Score

Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: University of Thessaly · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event. Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Conditions

• Stroke Ischemic
• Stroke Acute
• Posterior Circulation Brain Infarction
• Risk Score

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ASTRAL prognostic score	ASTRAL prognostic score

Timeline

• Start date: 2003-01-01
• Primary completion: 2021-12-31
• Completion: 2025-11-24
• First posted: 2023-06-15
• Last updated: 2025-04-08

Locations

2 sites across 2 countries: Greece, Switzerland