NCT05906342

Dose Response Relationship Between Fat Ingestion and Metabolism

Investigating the Effect of Acute Fat Ingestion on Glucose Metabolism in Young Healthy Adults: a Dose Response Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity. The main question this trial aims to answer is how does increasing fat quantity impact glucose tolerance, glucose and insulin metabolism, and hormones involved in hunger. Participant will consume four meals consisting of either 20, 40, 60, or 80% energy from fat.

Detailed description

The long-term consumption of high-fat foods can lead to unhealthy changes in the functioning of the body, giving rise to metabolic diseases such as type 2 diabetes. Similarly, short-term high-fat diets have also been shown to disrupt how the body performs but there is a lack of information regarding how a single high-fat meal can disrupt metabolism. Comparing meals of different fat quantity, without changing the overall energy intake (calories), will help us understand the short-term effect of fat ingestion on the functioning of the body and whether increasing the amount of fat in a meal is related to the level of dysfunction in the body. Therefore, the investigators will provide participants with four meals of varying fat quantity and in the period following the meal, the investigators will take blood samples to determine any changes that occur in the body in response to different levels of fat.

Conditions

• Glucose Tolerance Impaired

Interventions

Type	Name	Description
OTHER	20% fat meal	Provided to participants once throughout duration of study, contains 20% fat
OTHER	40% fat meal	Provided to participants once throughout duration of study, contains 40% fat
OTHER	60% fat meal	Provided to participants once throughout duration of study, contains 60% fat
OTHER	80% fat meal	Provided to participants once throughout duration of study, contains 80% fat

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-04-30
• Completion: 2024-04-30
• First posted: 2023-06-15
• Last updated: 2025-08-19

Locations

1 site across 1 country: Canada