NCT05903950

Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure

Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure: the APCIQ-BP Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Weill Cornell Medical College in Qatar · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over 4-weeks in patients with metabolic syndrome residing in Qatar.

Detailed description

Chronic cardio-metabolic diseases such as hypertension and diabetes contribute disproportionately to global morbidity and mortality and are increasing believed to have multiple environmental influences. PM2.5 is the fifth leading risk factor for global mortality - largely due to cardiovascular disease (CVD). Reducing personal exposure to air pollution has shown promise in improving key cardiovascular risk factors (blood pressure and insulin resistance) in limited studies, but durability of these effects is not known. Personal air cleaners have been shown to decrease personal exposure to PM2.5 and reduce blood pressure in small studies and may serve as a pragmatic intervention in high-risk patients in whom air pollution is a strong contributor to cardiovascular health.

Conditions

• Hypertension, Systolic
• Metabolic Syndrome

Interventions

Type	Name	Description
DEVICE	Air cleaners with HEPA filter	PM 2.5 exposure reduction using in home portable air cleaners fitted with HEPA filters
DEVICE	Air cleaners without HEPA filter	Simulation of PM 2.5 exposure reduction using in home portable air cleaners without HEPA filters.

Timeline

• Start date: 2024-11-03
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2023-06-15
• Last updated: 2025-07-20

Locations

1 site across 1 country: Qatar