NCT05900232

Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 17 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations. Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria. SLICC Criteria requires either that a patient satisfy at least 4 of 17 Criteria including at least 1 of 11 clinical criteria and 1 of 6 immunological criteria or the patient has biopsy -proven nephritis compatible with SLE in the presence of antinuclear antibodies (ANA)or anti\_double stranded DNA (dsDNA) antibodies. Anti\_KU antibodies included in (ANA), reported in many autoimmune disorders like SLE,Sjogren syndrome, idiopathic lung fibrosis and myositis. So the aim of the work is to determine the relationship between Anti\_KU antibodies and SLE manifestations.

Conditions

• Systemic Lupus Erythematosus

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Anti _KU antibodies	aim of the work is to determine the relationship between Anti\_Ku antibodies and SLE manifestations the study will include 60 SLE cases diagnosed by SLICC criteria and the activity of SLE will be calculated by SELDAI criteria, which is tool composed of 24 clinical and laboratory variables.

Timeline

• Start date: 2023-05-15
• Primary completion: 2023-10-15
• Completion: 2023-11-01
• First posted: 2023-06-12
• Last updated: 2023-06-12

Locations

1 site across 1 country: Egypt