NCT05899920

Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: Ryazan State Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study was planned to assess the concentration of antihypertensive drugs in the blood plasma in patients with controlled and uncontrolled arterial hypertension. Methods: it is planned to include patients with arterial hypertension taking 3 antihypertensive drugs (indapanide, lisinopril or valsartan, amlodipine). Based on the results of 24-hour blood pressure monitoring, the patients will be randomized into two groups: The first group - the patients with controlled AH; The second group - the patients with uncontrolled AH. Venous blood was taken in both groups of the patients in the morning before and 2 hours after taking drugs to assess the concentration of lisinopril, amlodipine, valsartan and indapamide. Concentation of assesed antihypertensive drugs will be compared in both groups.

Conditions

• Resistant Arterial Hypertension

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood samples will be taken for pharmacokinetics and pharmacogenetics	To assess antihypertensive drugs concentration (lisinopril, valsartan, amlodipine, indapamide

Timeline

• Start date: 2022-03-11
• Primary completion: 2024-11-11
• Completion: 2024-12-31
• First posted: 2023-06-12
• Last updated: 2024-04-24

Locations

1 site across 1 country: Russia